Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.
包装
1 g in glass bottle
25, 100, 250 mg in glass bottle
性质
Related Categories
Antibiotics, Antibiotics A to Z, Antibiotics A-F,Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,
